New FDA Approval: IZERVAY

The FDA’s recent approval of IZERVAY (avacincaptad pegol), developed by Iveric Bio and acquired by Astellas Pharma, offers new hope for patients suffering from geographic atrophy (GA) secondary to age-related macular degeneration (AMD). This marks a significant step forward in the treatment of this condition, which affects over 1.5 million people in the United States and is a leading cause of irreversible vision loss.

IZERVAY, a complement C5 inhibitor, has demonstrated a statistically significant reduction in the progression of GA after 12 months. This is particularly noteworthy as GA, a condition resulting from the progression of AMD, has previously had limited treatment options. The GATHER1 and GATHER2 Phase 3 clinical trials showcased the efficacy of IZERVAY, with some patients observing a slowing in the progression of GA as early as 6 months, and others experiencing up to a 35% reduction in the first year. The trials also noted that IZERVAY was more effective in reducing GA progression than any currently approved medication.

It’s important to be aware of the potential adverse reactions associated with IZERVAY. The most common ones reported during the GATHER clinical trials include conjunctival hemorrhage, increased intraocular pressure, and blurred vision. However, these reactions affected a relatively small percentage of the trial population.

For patients of Compton Eye Associates, the approval of IZERVAY opens up a promising new treatment option for those suffering from GA secondary to AMD. Our team is committed to providing the latest and most effective treatments to ensure the best possible care for your eye health. We encourage those affected by GA or AMD to consult with our healthcare professionals to discuss whether IZERVAY is an appropriate treatment option for their specific condition.

To learn more about IZERVAY and its potential benefits and risks, or to explore treatment options for geographic atrophy, we welcome you to schedule an appointment at our office. Our dedicated team is here to provide the latest and most effective treatments, ensuring the best possible care for your eye health.